Herpes simplex - Hérpes Simplex
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Herpes simplex (herpes simpléks) dina biwir.
Hérpes Simplex (Herpes simplex) ― Inféksi herpes simpléks dina ramo leuwih umum di barudak ngora tibatan déwasa.
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ReferencesInféksi HSV-1 lumangsung ngaliwatan inféksi primér sél épitél, dituturkeun ku fase laten, utamana dina neuron, sarta reaktivasi. HSV-1 ilaharna nyababkeun letusan vesikular anu mimiti jeung rékurrén, khususna dina sungut jeung mukosa séksual. Manifestasina rupa‑rupa, ti herpes orolabial nepi ka kaayaan séjén sapertos folliculitis herpetic, inféksi kulit, keterlibatan ocular, sarta kasus parna sapertos herpes encephalitis. Terapi antiviral ngabantu ngatur inféksi HSV.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) mangrupakeun inféksi nu nyebar, mangaruhan kira‑kira 22 % tina jalma dewasa umur 12 taun ka luhur, kalayan total 45 juta jalma dewasa di Amérika Serikat. Sedengkeun HSV-1 ilaharna nyababkeun sores lisan, éta ogé tiasa nyababkeun lesions séks. Sanajan kitu, lamun penderita ngagaduhan lesions séks, HSV-2 biasana janten perhatian utama. Gejala HSV-2 sering samar, sapertos gatel séks jeung iritasi, anu tiasa ngalambatkeun diagnosis jeung pengobatan. Panundaan ieu tiasa nyababkeun transmisi salajengna ka jalma anu teu katépaan.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) ilaharna nyababkeun inféksi sapertos herpes séks sareng sores tiis dina rumaja jeung déwasa. Nalika HSV nginféksi orok dina 4‑6 minggu kahiji kahirupan, éta tiasa nyababkeun panyakit parna jeung akibat anu serius. Diagnosa gancang inféksi HSV neonatal penting pisan pikeun nyegah panyakit jadi parah, sarta nyegah komplikasi neurologis (malah maot).
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex inféksi umum pisan sareng tiasa ditularkeun ti ibu hamil ka orokna. Virus ieu tiasa nyababkeun masalah kaséhatan anu serius atanapi bahkan maot dina bayi anu énggal. Sedengkeun éta langka nalika kakandungan sorangan, éta mindeng lumangsung nalika ngalahirkeun. Résiko pangluhurna upami indungna katépaan dina tahap ahir kakandungan. Nanging, résiko ieu tiasa dikirangan ku ngagunakeun obat antiviral atanapi milih bagian C dina kaayaan anu tangtu.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) jinis 1 sareng 2 nginféksi seueur jalma di dunya. Biasana, virus tetep sepi dina sél saraf sanggeus nginféksi kulit, tapi tiasa aktip deui engké, nyababkeun nyeri tiis. Kadang, éta tiasa nyababkeun komplikasi parah sapertos inféksi panon, radang otak, atawa kaayaan bahaya dina orok anyar lahir jeung jalma anu sistem imunnya lemah. Sanajan ubar ayeuna tiasa ngabantosan ngontrol inféksi, résiko résistansi ubar jeung efek samping tetep jadi perhatian. Urang peryogi ubar anyar pikeun nargétkeun virus kalayan leuwih efektif.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Aya dua jinis virus hérpes simplex (herpes simplex), nyaéta tipe 1 (HSV-1) jeung tipe 2 (HSV-2). HSV-1 leuwih ilahar nyababkeun inféksi di sabudeureun sungut, sedengkeun HSV-2 leuwih ilahar nyababkeun inféksi séksual. Virus ieu ditularkeun ku kontak langsung jeung jalma anu katépaan. Herpes séks digolongkeun kana inféksi anu ditularkeun sacara seksual. Virus ogé tiasa sumebar ka orok nalika ngalahirkeun. Sanggeus inféksi, virus diangkut sapanjang saraf indrawi ka sél saraf, dimana éta cicing salami hirup. Faktor‑faktor anu bisa nyababkeun kambuh di antarana: turunna fungsi imun, setrés, jeung paparan sinar panonpoé.
Dina kalolobaan kasus, ubar antiviral dipaké ngan lamun gejala parah. Pangobatan antiviral poéan tiasa diresepkeun ka jalma anu sering ngalaman inféksi. Henteu aya vaksin anu sayogi pikeun herpes simplex, sarta vaksin shingles henteu nyegah inféksi ieu. Ubar antiviral sapertos aciclovir atawa valaciclovir tiasa ngirangan parahna gejala.
Prevalénsi HSV-1 jeung HSV-2 di sakuliah dunya antara 60 % nepi ka 95 % dina populasi déwasa. HSV-1 biasana kainféksi nalika budak leutik. Diperkirakeun aya 536 juta jalma di dunya (16 % tina populasi) anu kainféksi HSV-2 dina taun 2003, kalayan tingkat anu leuwih luhur di antara awéwé jeung jalma di nagara‑nagari nu keur ngembang. Kalolobaan jalma anu boga HSV-2 teu sadar yén maranéhna kainféksi.
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